Review: Free mobile-friendly Web design frameworks
Twitter Bootstrap, HTML5 Boilerplate, 52Framework, and 320 and Up take the sting out of building websites for both large and small screens
Yet another variant is the Golden Grid System (MIT License), which sports 18 columns that are proportional across the width of the browser. Those columns telescope into each other for smaller-sized displays, with the spaces between columns also changing proportionally. Better still, font sizes can scale proportionally, so the vertical aspect of the page also adjusts with resizing. Again, very little is included -- just enough to get a design started.
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