Job hunting, with a twist

Dear Bob ...

I'm a techie, currently underemployed at a small firm where my boss has told me that there is a "good chance" I'm going to be laid off next month (not surprising; the company has struggled off and on with bankruptcy for some time). That being the case, I have changed the mode on my job hunt from "sporadically half-hearted" to "active". None of this is particularly unusual. However, my own situation has a twist.

I have a condition called Asperger Syndrome, which means that I need certain accommodations to be able to do my work effectively, the main ones being a high degree of solitude and a very quiet environment (other things would be helpful as well, but those two are by far the most important). This isn't simply a personal preference, as it is with many other people; if I don't have these things, I simply can't work. When, if ever, should I discuss this during the job search?

Would it be better for me to simply ask during interviews, for example, what kind of environment the company has, and then gracefully say that it would be a bad match if the company describes itself as "fast-paced"? (Which is a euphemism for noisy and people-oriented, of course.)

If an interviewer asks me whether I have any disabilities that might "impede my ability to perform the job", how should I respond?