"Building a great game service is really hard. Building a great music service is really hard. Building a great movie service is really hard," he said.
That's why, in his view, the best innovations come from small, independent entrepreneurial companies, and much less often from divisions within large corporations.
Zuckerberg told Rose that he was very flattered by the praise he received from Steve Jobs in the recently-published biography of the late Apple co-founder.
In that book by Walter Isaacson, Jobs is quoted as saying that he admired and respected Zuckerberg for not selling Facebook and instead opting to grow and develop the company. "I took it as this amazing compliment," Zuckerberg said.
In conversations with Jobs, Zuckerberg sought his advice about things like how to assemble an outstanding team and how to keep the company focused, he said.
Zuckerberg also argued that when it comes to online advertising that's targeted based on users' behavior, Facebook gives people more transparency and control than ad networks from the likes of Google, Microsoft and Yahoo, which in his view track people in a stealthy way through silent cookies.
Facebook matches ads to different user audiences based on information the members have voluntarily entered into the system via their profiles and actions, he said.
Juan Carlos Perez covers search, social media, online advertising, e-commerce, web application development, enterprise cloud collaboration suites and general technology breaking news for the IDG News Service. Follow Juan on Twitter at @JuanCPerezIDG.